Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9039983 | 0.88 | MAPK8 (0.47) | LMNAMAPK8TDP1KMT2AMEN1 | |
| SCHEMBL9041248 | 0.82 | TDP1 (0.53) | KDM4EMAPTMAPK8TDP1KMT2A | |
| SCHEMBL5780757 | 0.81 | SLC13A5 (0.58) | KDM4ECYP1A2MAPTHSD17B10TDP1 | |
| SCHEMBL7374241 | 0.80 | TDP1 (0.59) | LMNAKDM4EMAPTMAPK8TDP1 | |
| SCHEMBL4166291 | 0.79 | KCNA5 (0.59) | LMNAKDM4ECYP1A2MAPTHSD17B10 | |
| SCHEMBL11479264 | 0.79 | MAPK8 (0.42) | KDM4ECYP1A2MAPTMAPK8TDP1 | |
| SCHEMBL9152146 | 0.78 | SLC1A5 (0.57) | LMNAKDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL9043422 | 0.77 | HIF1A (0.48) | MAPK8TDP1KMT2AMEN1RAB9A | |
| SCHEMBL9041764 | 0.77 | TDP1 (0.44) | MAPK8TDP1KMT2AMEN1HTT | |
| SCHEMBL9487325 | 0.77 | TDP1 (0.59) | MAPTMAPK8TDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024371-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007134434-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-11-29 | — | — | WO | disclosed |