Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.38 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.36 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056148 | 0.92 | SLC6A2 (0.40) | SLC6A2ABHD6DAGLAEPHA2NR1H4 | |
| SCHEMBL3605770 | 0.86 | SLC6A2 (0.67) | SLC6A2SLC6A3SLC6A4USP30 | |
| SCHEMBL4062934 | 0.85 | SLC6A2 (0.49) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL3604646 | 0.84 | SLC6A2 (0.50) | SLC6A2SLC6A3EPHA2SLC6A4 | |
| SCHEMBL3605773 | 0.79 | SLC6A2 (0.53) | SLC6A2SLC6A3EPHA2SLC6A4USP30 | |
| SCHEMBL4063312 | 0.78 | SLC6A2 (0.53) | SLC6A2SLC6A3SLC6A4USP30 | |
| SCHEMBL3604644 | 0.78 | SLC6A2 (0.41) | SLC6A2SLC6A3EPHA2SLC6A4USP30 | |
| SCHEMBL4062931 | 0.77 | SLC6A2 (0.41) | SLC6A2EPHA2NR1H4USP30ERBB2 | |
| SCHEMBL3600999 | 0.76 | SLC6A2 (0.67) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4063320 | 0.73 | SLC6A2 (0.44) | SLC6A2EPHA2SLC6A4USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |