Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | FYN | P06241 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | PRKCB | P05771 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | HCK | P08631 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053112 | 0.95 | BRAF (0.51) | BRAFMAPK14FYNCHEK1ABL1 | |
| SCHEMBL4053927 | 0.89 | BRAF (0.50) | BRAFMAPK14ABL1MAPK8 | |
| SCHEMBL4051889 | 0.87 | BRAF (0.50) | BRAFMAPK14FYNCHEK1ABL1 | |
| SCHEMBL4050624 | 0.85 | BRAF (0.51) | BRAFMAPK14FYNCHEK1ABL1 | |
| SCHEMBL4051319 | 0.85 | BRAF (0.56) | BRAFMAPK14FYNCHEK1ABL1 | |
| SCHEMBL4053503 | 0.84 | BRAF (0.51) | BRAFMAPK14 | |
| SCHEMBL4056069 | 0.84 | BRAF (0.56) | BRAFMAPK14FYNCHEK1ABL1 | |
| SCHEMBL4051286 | 0.83 | BRAF (0.51) | BRAFMAPK14MAPK8MAPK9MAPK10 | |
| SCHEMBL4050373 | 0.79 | BRAF (0.49) | BRAFMAPK14FYNCHEK1ABL1 | |
| SCHEMBL4050676 | 0.77 | BRAF (0.51) | BRAFMAPK14FYNCHEK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111260-A1 | PHENYLSULFONAMIDE-SUBSTITUTED, PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-11 | — | — | WO | disclosed |