Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estradiol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 7/20 | 0.77 |
| ▸ | LMNA | P02545 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.77 |
| ▸ | PGR | P06401 | 3/20 | 0.77 |
| ▸ | AR | P10275 | 3/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.77 |
| ▸ | STS | P08842 | 2/20 | 0.77 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.77 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alfatradiol SCHEMBL22092636 | 1.00 | ESR1 (0.77) | ESR1LMNAMAPTKMT2AESR2 | |
| Estradiol SCHEMBL8001333 | 1.00 | ESR1 (0.77) | ESR1LMNAMAPTKMT2AESR2 | |
| Estradiol SCHEMBL7638916 | 1.00 | ESR1 (0.77) | ESR1LMNAMAPTKMT2AESR2 | |
| Estradiol SCHEMBL7186616 | 1.00 | ESR1 (0.77) | ESR1LMNAMAPTKMT2AESR2 | |
| Estradiol SCHEMBL26659961 | 0.97 | ESR1 (0.75) | ESR1LMNAMAPTKMT2AESR2 | |
| Estradiol SCHEMBL28365778 | 0.96 | ESR1 (0.71) | ESR1LMNAMAPTKMT2AESR2 | |
| Estradiol SCHEMBL17419455 | 0.96 | ESR1 (0.74) | ESR1LMNAMAPTKMT2AESR2 | |
| Stearic Acid SCHEMBL7751689 | 0.96 | ESR1 (0.74) | ESR1LMNAMAPTKMT2AESR2 | |
| Estradiol SCHEMBL547939 | 0.96 | ESR1 (0.74) | ESR1LMNAMAPTKMT2AESR2 | |
| Estradiol SCHEMBL26659977 | 0.96 | ESR1 (0.74) | ESR1LMNAMAPTKMT2AESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7069 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20260027215-A1 | COMPOSITIONS FOR TRANSPORT OF THERAPEUTIC CARGOS USING BINDERS TARGETING CA-IV | RECEPTIVE BIO INC (US) | 2026-01-29 | — | — | US | claimed |
| EP-4608425-A1 | METHODS OF TREATING ESTROGEN SENSITIVE DISEASES WITH CANNABIS EXTRACT | Ecofibre USA Inc. (US) | 2025-09-03 | — | — | EP | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-12364682-B2 | Use of tegaserod in preparation of anti-tumor drug | QINGDAO HAIJI BIOMEDICINE CO., LTD. (CN) | 2025-07-22 | — | — | US | claimed |
| CN-120131073-A | Clinical pregnancy prediction method after frozen embryo transplantation based on ultrasonic radiology group | 安徽医科大学第一附属医院 | 2025-06-13 | — | — | CN | claimed |
| US-20250191770-A1 | COMPUTERIZED DECISION SUPPORT TOOL AND MEDICAL DEVICE FOR RESPIRATORY CONDITION MONITORING AND CARE | PFIZER INC. (US) | 2025-06-12 | — | — | US | claimed |
| US-12310928-B2 | Enthesis healing | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2025-05-27 | — | — | US | claimed |
| CN-119857071-A | High-efficiency external medicine for repairing leukoplakia vulvae and preparation method thereof | 韩志君 | 2025-04-22 | — | — | CN | claimed |
| EP-4531594-A1 | PREVENTION OF ESTRUS IN SOW AND RUMINANTS | Insigna Inc. (US) | 2025-04-09 | — | — | EP | claimed |
| EP-0309263-A2 | Hormone composition and use | JENCAP RESEARCH LIMITED (CA) | 1989-03-29 | — | — | EP | claimed |
| EP-0269696-A1 | TRANSDERMAL ABSORPTION DOSAGE UNIT FOR ESTRADIOL AND OTHER ESTROGENIC STEROIDS. | UNIV NEW JERSEY (US) | 1988-06-08 | — | — | EP | claimed |
| EP-0256668-A2 | Method for treating male sexual dysfunction | UNIVERSITY OF FLORIDA (US) | 1988-02-24 | — | — | EP | claimed |
| WO-1987007138-A1 | TRANSDERMAL ABSORPTION DOSAGE UNIT FOR ESTRADIOL AND OTHER ESTROGENIC STEROIDS AND PROCESS FOR ADMINISTRATION | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1987-12-03 | — | — | WO | claimed |
| EP-0220844-A2 | Use of estrogen-dihydropyridine compounds for weight control | UNIVERSITY OF FLORIDA (US) | 1987-05-06 | — | — | EP | claimed |
| US-4617298-A | STEROIDS | UNIVERSITY OF FLORIDA (US) | 1986-10-14 | — | — | US | claimed |
| EP-0136011-A2 | A method of hormonal treatment of peri-menopausal, menopausal and post-menopausal disorders and multi-preparation pack therefor | PRE JAY HOLDINGS LTD. (CA) | 1985-04-03 | — | — | EP | claimed |
| US-4330538-A | Use of estradiol valerate as an anti-depressant | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-05-18 | — | — | US | claimed |
| US-4145416-A | ESTRADIOL AND ESTRIOL DERIVATIVES | SCHERING, A.G. (DE) | 1979-03-20 | — | — | US | claimed |
| US-4076811-A | MENOPAUSE, ESTRADIOL ESTROGEN | SCHERING AKTIENGESELLSCHAFT (DT) | 1978-02-28 | — | — | US | claimed |