Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 18/20 | 0.62 |
| ▸ | HRH1 | P35367 | 2/20 | 0.62 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.62 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3776444 | 0.89 | SSTR5 (0.68) | SSTR5HRH1SSTR1HTR2BKCNH2 | |
| SCHEMBL3782654 | 0.85 | SSTR5 (0.62) | SSTR5HRH1SSTR1HTR2BKCNH2 | |
| SCHEMBL3782537 | 0.84 | SSTR5 (0.63) | SSTR5HRH1SSTR1HTR2BKCNH2 | |
| SCHEMBL3787442 | 0.83 | SSTR5 (0.67) | SSTR5HRH1SSTR1HTR2BKCNH2 | |
| SCHEMBL3774424 | 0.82 | SSTR5 (0.58) | SSTR5HRH1SSTR1HTR2BKCNH2 | |
| SCHEMBL1122072 | 0.82 | SSTR5 (0.80) | SSTR5HRH1SSTR1HTR2B | |
| SCHEMBL2417926 | 0.81 | SSTR5 (0.68) | SSTR5HRH1SSTR1HTR2BKCNH2 | |
| SCHEMBL3776489 | 0.81 | SSTR5 (0.56) | SSTR5HRH1SSTR1HTR2BKCNH2 | |
| SCHEMBL4227219 | 0.80 | SSTR5 (0.56) | SSTR5HRH1SSTR1HTR2BKCNH2 | |
| SCHEMBL3781218 | 0.80 | SSTR5 (0.58) | SSTR5HRH1SSTR1HTR2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-B1 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | claimed |