Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 14/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224004 | 0.88 | PIK3CA (0.74) | PIK3CBPIK3CGPIK3CDPIK3CAPOLB | |
| SCHEMBL1749438 | 0.87 | PIK3CB (0.55) | PIK3CBPIK3CGPIK3CDPIK3CACSNK1D | |
| SCHEMBL1749439 | 0.87 | PIK3CB (0.55) | PIK3CBPIK3CGPIK3CDPIK3CACSNK1D | |
| SCHEMBL1749660 | 0.76 | PIK3CA (0.66) | PIK3CBPIK3CGPIK3CDPIK3CA | |
| SCHEMBL1750563 | 0.76 | PIK3CB (0.70) | PIK3CBPIK3CGPIK3CDPIK3CA | |
| SCHEMBL301214 | 0.75 | PIK3CB (0.80) | PIK3CBPIK3CGPIK3CDPIK3CATP53 | |
| SCHEMBL300841 | 0.75 | PIK3CB (0.80) | PIK3CBPIK3CGPIK3CDPIK3CATP53 | |
| SCHEMBL301311 | 0.74 | PIK3CB (0.85) | PIK3CBPIK3CGPIK3CDPIK3CA | |
| SCHEMBL300949 | 0.74 | PIK3CB (1.00) | PIK3CBPIK3CGPIK3CDPIK3CA | |
| SCHEMBL301238 | 0.73 | PIK3CB (0.98) | PIK3CBPIK3CGPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051494-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |