Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 16/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.32 |
| ▸ | RBPJ | Q06330 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056590 | 0.86 | SLC6A2 (0.47) | SLC6A2SLC6A3KCNH2SLC6A4 | |
| SCHEMBL4055117 | 0.80 | SLC6A2 (0.36) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4055289 | 0.79 | PIM1 (0.36) | SLC6A2SLC6A3SLC6A4 | |
| Hydrochloric Acid SCHEMBL4939183 | 0.79 | SLC6A2 (0.36) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4061650 | 0.78 | SLC6A2 (0.45) | SLC6A2SLC6A3KCNH2SLC6A4 | |
| SCHEMBL4054212 | 0.78 | SLC6A2 (0.35) | SLC6A2TP53SLC6A3KCNH2SLC6A4 | |
| SCHEMBL4061668 | 0.77 | SLC6A2 (0.55) | SLC6A2SLC6A3KCNH2SLC6A4 | |
| SCHEMBL4063223 | 0.76 | SLC6A2 (0.39) | SLC6A2TP53SLC6A3KCNH2SLC6A4 | |
| SCHEMBL4054996 | 0.76 | SLC6A2 (0.51) | SLC6A2SLC6A3KCNH2SLC6A4 | |
| SCHEMBL4054219 | 0.76 | SLC6A2 (0.36) | SLC6A2TP53SLC6A3KCNH2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | claimed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | claimed |