Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.79 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052381 | 0.95 | MTOR (0.86) | MTORPIK3CAPIK3R1PIK3CG | |
| SCHEMBL4050285 | 0.88 | MTOR (1.00) | MTORPIK3CAPIK3R1PIK3CG | |
| SCHEMBL4058302 | 0.88 | MTOR (0.84) | MTORPIK3CAPIK3R1 | |
| SCHEMBL4050757 | 0.88 | MTOR (0.79) | MTORPIK3CAPIK3R1PIK3CG | |
| SCHEMBL4053948 | 0.86 | MTOR (0.84) | MTORPIK3CAPIK3R1 | |
| SCHEMBL4051368 | 0.86 | MTOR (0.83) | MTORPIK3CAPIK3CG | |
| SCHEMBL4058503 | 0.85 | MTOR (0.81) | MTORPIK3CAPIK3R1PIK3CG | |
| SCHEMBL4052500 | 0.84 | MTOR (0.80) | MTORPIK3CAPIK3R1 | |
| SCHEMBL4059830 | 0.84 | MTOR (0.67) | MTORPIK3CAPIK3R1PIK3CG | |
| SCHEMBL4056208 | 0.83 | MTOR (0.79) | MTORPIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111547-A1 | 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH (US) | 2009-09-11 | — | — | WO | disclosed |