Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 9/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1399511 | 0.96 | TSHR (0.44) | TSHRHPGDTHRBALDH1A1TP53 | |
| SCHEMBL305936 | 0.81 | TSHR (0.41) | TSHRHPGDTHRBALDH1A1TP53 | |
| SCHEMBL5576390 | 0.81 | TSHR (0.44) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL8605064 | 0.80 | TSHR (0.40) | TSHRHPGDTHRBALDH1A1TP53 | |
| SCHEMBL11320956 | 0.80 | TSHR (0.40) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL278175 | 0.79 | TSHR (0.42) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL3281067 | 0.79 | TSHR (0.47) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL377120 | 0.79 | TSHR (0.46) | TSHRHPGDTHRBALDH1A1CYP3A4 | |
| SCHEMBL11870880 | 0.79 | TSHR (0.39) | TSHRHPGD | |
| Chloromethane SCHEMBL19549279 | 0.79 | TSHR (0.41) | TSHRHPGDTHRBALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109441-A2 | POLYSILOXANE BLOCK COPOLYMERS | Ciba Holding Inc. (CH) | 2009-10-21 | — | — | EP | disclosed |
| WO-2008095822-A2 | POLYSILOXANE BLOCK COPOLYMERS | CIBA HOLDING INC. (CH) | 2008-08-14 | — | — | WO | disclosed |