SCHEMBL4057773

SCHEMBL4057773

Cc1sc(N2CCN(c3ccc(Cl)cc3)CC2)nc1CCOc1cccc(CC(=O)O)c1

nearest known ligand 0.55

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PPARG P37231 15/20 0.55
PPARA Q07869 10/20 0.55
PPARD Q03181 10/20 0.55
DRD2 P14416 1/20 0.46
DRD4 P21917 1/20 0.46
DRD3 P35462 1/20 0.46
CYP2C9 P11712 1/20 0.43
MAPT P10636 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
ITGB3 P05106 1/20 0.41
ITGA2B P08514 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4065302 0.93 PPARG (0.48) PPARGPPARAPPARDITGB3ITGA2B
SCHEMBL4056042 0.93 PPARG (0.49) PPARGPPARAPPARDMAPTITGB3
SCHEMBL4389495 0.88 PPARG (0.54) PPARGPPARAPPARD
SCHEMBL4061597 0.86 PPARD (0.61) PPARGPPARAPPARDMAPTSMN1; SMN2
SCHEMBL4056282 0.82 PPARG (0.54) PPARGPPARAPPARD
SCHEMBL4055139 0.81 PPARD (0.41) PPARGPPARAPPARDMAPTSMN1; SMN2
SCHEMBL4401435 0.79 PPARG (0.51) PPARGPPARAPPARDMAPT
SCHEMBL4061841 0.79 PPARD (0.55) PPARGPPARAPPARD
SCHEMBL4392757 0.75 PPARG (0.61) PPARGPPARA
SCHEMBL14514210 0.75 PLA2G4B (0.48) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1666472-B1 PHENYLACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE ONO PHARMACEUTICAL CO (JP) 2012-08-01 EP disclosed
US-7560475-B2 Phenylacetic acid derivative, process for producing the same, and use ONO PHARMACEUTICAL CO., LTD. (JP) 2009-07-14 US disclosed
US-20070105868-A1 Phenylacetic acid derivative, process for producing the same, and use ONO PHARMACEUTICAL CO., LTD. (JP) 2007-05-10 US disclosed
EP-1666472-A1 PHENYLACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE ONO PHARMACEUTICAL CO., LTD. (JP) 2006-06-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070105868-A1 Phenylacetic acid derivative, process for producing the same, and use PPARA, PPARD, PPARG PPARG 3/4885PPARA 1/4885PPARD 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.