Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 19/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 17/20 | 0.52 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.45 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3086928 | 0.89 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL3099422 | 0.83 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1 | |
| SCHEMBL3096745 | 0.80 | HSP90AA1 (0.72) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL3089646 | 0.75 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1 | |
| SCHEMBL3085876 | 0.75 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1 | |
| SCHEMBL3094490 | 0.75 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL3793290 | 0.74 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL3097357 | 0.74 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL4238636 | 0.74 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1TRAP1HSP90B1 | |
| SCHEMBL3091011 | 0.74 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1TRAP1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109612-A2 | 5,6,7,8-TETRAHYDROPTERIDINE DERIVATIVES AS HSP90 INHIBITORS | AstraZeneca AB (SE) | 2009-10-21 | — | — | EP | claimed |
| WO-2008093075-A2 | 5,6,7,8-TETRAHYDROPTERIDINE DERIVATIVES AS HSP90 INHIBITORS | ASTRAZENECA AB (SE) | 2008-08-07 | — | — | WO | claimed |
| EP-2109612-A2 | 5,6,7,8-TETRAHYDROPTERIDINE DERIVATIVES AS HSP90 INHIBITORS | AstraZeneca AB (SE) | 2009-10-21 | — | — | EP | disclosed |
| WO-2008093075-A2 | 5,6,7,8-TETRAHYDROPTERIDINE DERIVATIVES AS HSP90 INHIBITORS | ASTRAZENECA AB (SE) | 2008-08-07 | — | — | WO | disclosed |