Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.88 |
| ▸ | INSR | P06213 | 10/20 | 0.88 |
| ▸ | NPM1 | P06748 | 8/20 | 0.88 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.73 |
| ▸ | PLK4 | O00444 | 1/20 | 0.64 |
| ▸ | BUB1B | O60566 | 1/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | FES | P07332 | 1/20 | 0.64 |
| ▸ | LYN | P07948 | 1/20 | 0.64 |
| ▸ | RET | P07949 | 1/20 | 0.64 |
| ▸ | IGF1R | P08069 | 1/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.64 |
| ▸ | MET | P08581 | 1/20 | 0.64 |
| ▸ | ROS1 | P08922 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1069403 | 0.93 | ALK (1.00) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL4048849 | 0.91 | ALK (0.88) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL1546149 | 0.89 | ALK (0.89) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL18018794 | 0.86 | ALK (0.68) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL12245856 | 0.86 | ALK (0.74) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL12388844 | 0.85 | ALK (0.84) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL23637757 | 0.85 | ALK (0.87) | ALKINSRNPM1KCNH2PLK4 | |
| SCHEMBL14478221 | 0.85 | ALK (0.84) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL1545609 | 0.85 | ALK (1.00) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL29537500 | 0.85 | ALK (1.00) | ALKINSRNPM1KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032703-A1 | 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS | IRM LLC (BM) | 2009-03-12 | — | — | WO | claimed |
| WO-2009032694-A1 | AMINO SUBSTITUTED PYRIMIDINE, PYROLLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS AND IN TREATING PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | DANA FARBER CANCER INSTITUTE (US) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032703-A1 | 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS | IRM LLC (BM) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032703-A1 | 2- (HET) ARYLAMINO-6-AMINOPYRIDINE DERIVATIVES AND FUSED FORMS THEREOF AS ANAPLASTIC LYMPHOMA KINASE INHIBITORS | IRM LLC (BM) | 2009-03-12 | — | — | WO | disclosed |