Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062189 | 0.87 | SYK (0.48) | SYKAURKAAURKB | |
| SCHEMBL4065581 | 0.85 | SYK (0.74) | SYKAURKAAURKB | |
| SCHEMBL4060292 | 0.77 | SYK (0.74) | SYKAURKAAURKB | |
| SCHEMBL4055446 | 0.75 | SYK (0.73) | SYKAURKAAURKB | |
| SCHEMBL4059070 | 0.75 | SYK (0.57) | SYKAURKAAURKB | |
| SCHEMBL4067531 | 0.75 | SYK (0.70) | SYKAURKAAURKB | |
| SCHEMBL4066289 | 0.74 | SYK (0.53) | SYKAURKAAURKB | |
| SCHEMBL4268551 | 0.73 | SYK (0.68) | SYKAURKAAURKB | |
| SCHEMBL4067099 | 0.73 | SYK (0.68) | SYKAURKAAURKB | |
| SCHEMBL4057028 | 0.73 | SYK (0.92) | SYKAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794148-B1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-04-15 | — | — | EP | claimed |