Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.49 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.49 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.49 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.49 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4060348 | 0.99 | CDK1 (0.49) | CDK1DYRK3CDK2GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL3190961 | 0.91 | EGLN1 (0.48) | CDK1DYRK3CDK2GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL27601574 | 0.90 | DYRK3 (0.47) | CDK1DYRK3CDK2GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL28760095 | 0.89 | CDK1 (0.47) | CDK1DYRK3CDK2GSK3BCDK7 | |
| SCHEMBL941764 | 0.84 | CDK1 (0.48) | CDK1DYRK3CDK2GSK3BCDK7 | |
| SCHEMBL2130483 | 0.81 | CDK5 (0.55) | CDK1DYRK3CDK2GSK3BCDK7 | |
| SCHEMBL2128792 | 0.79 | DYRK3 (0.52) | CDK1DYRK3CDK2GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL3192660 | 0.79 | EGLN1 (0.48) | CDK1DYRK3CDK2GSK3BCDK7 | |
| SCHEMBL4061600 | 0.78 | CDK2 (0.47) | CDK1DYRK3CDK2GSK3BCDK7 | |
| SCHEMBL4059910 | 0.77 | CDK1 (0.48) | CDK1DYRK3CDK2GSK3BCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-B9 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | claimed |
| EP-1492785-B1 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-03 | — | — | EP | claimed |