Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 5/20 | 0.38 |
| ▸ | HTR2C | P28335 | 5/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060313 | 0.89 | SLC6A2 (0.54) | SLC6A2SLC6A3SLC6A4GRM5EEF2K | |
| SCHEMBL3599868 | 0.82 | PLK1 (0.41) | SLC6A2SLC6A3EEF2KLMNA | |
| SCHEMBL4059629 | 0.77 | PLK1 (0.43) | SLC6A2SLC6A3 | |
| SCHEMBL3601988 | 0.77 | SLC6A2 (0.59) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL3615703 | 0.76 | TP53 (0.43) | LMNA | |
| SCHEMBL3604006 | 0.76 | SLC6A2 (0.44) | SLC6A2SLC6A3SLC6A4HTT | |
| SCHEMBL4057590 | 0.76 | SLC6A2 (0.47) | SLC6A2SLC6A3SLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL3610819 | 0.76 | SLC6A2 (0.58) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL3601735 | 0.75 | PLK1 (0.41) | LMNA | |
| SCHEMBL4062472 | 0.75 | CHRM2 (0.43) | SLC6A2SLC6A3GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |