Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 7/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.66 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | PRKDC | P78527 | 1/20 | 0.52 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.52 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27963145 | 0.83 | PIK3CD (0.78) | PIK3CGPIK3CDPIK3CAPIK3CBMAPT | |
| SCHEMBL188557 | 0.82 | PIK3CD (0.84) | PIK3CGPIK3CDPIK3CAPIK3CBMAPT | |
| SCHEMBL188977 | 0.81 | PIK3CG (0.87) | PIK3CGPIK3CDPIK3CAPIK3CBMAPT | |
| SCHEMBL2305680 | 0.81 | PIK3CG (0.70) | PIK3CGPIK3CDPIK3CAPIK3CBMAPT | |
| SCHEMBL1790535 | 0.81 | PIK3CD (0.70) | PIK3CGPIK3CDPIK3CAPIK3CBMAPT | |
| SCHEMBL2301857 | 0.80 | PIK3CD (0.83) | PIK3CGPIK3CDPIK3CAPIK3CBMAPT | |
| SCHEMBL189335 | 0.80 | PIK3CD (0.76) | PIK3CGPIK3CDPIK3CAPIK3CBMAPT | |
| SCHEMBL189424 | 0.80 | PIK3CD (0.69) | PIK3CGPIK3CDPIK3CAPIK3CBMAPT | |
| SCHEMBL188834 | 0.80 | PIK3CD (0.79) | PIK3CGPIK3CDPIK3CAPIK3CBMAPT | |
| SCHEMBL2305856 | 0.80 | PIK3CD (0.76) | PIK3CGPIK3CDPIK3CAPIK3CBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2009506015-A | — | — | 2009-02-12 | — | — | JP | claimed |
| EP-1917252-A1 | PYRAZINE DERIVATIVES AND USE AS PI3K INHIBITORS | LABORATOIRES SERONO S.A. (CH) | 2008-05-07 | — | — | EP | claimed |
| WO-2007023186-A1 | PYRAZINE DERIVATIVES AND USE AS PI3K INHIBITORS | LABORATOIRES SERONO S.A. (CH) | 2007-03-01 | — | — | WO | claimed |
| CN-103819416-A | N-(3-amino-quinoxalin-2-yl)-sulfonamide derivatives and their use as phosphatidylinositol 3-kinase inhibitors | EXELIXIS INC | 2014-05-28 | — | — | CN | disclosed |