Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 15/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.58 |
| ▸ | ATR | Q13535 | 1/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | AKT2 | P31751 | 1/20 | 0.49 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056538 | 0.91 | PIK3CA (0.67) | FYNPIK3CAATRPIK3CDPIK3CB | |
| SCHEMBL4061772 | 0.90 | FYN (0.71) | FYNPIK3CAATRPIK3CDPIK3CB | |
| SCHEMBL13595838 | 0.87 | PIK3CA (0.67) | FYNPIK3CAATRPIK3CDPIK3CB | |
| SCHEMBL4058369 | 0.83 | PIK3CD (0.54) | FYNPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4053277 | 0.82 | PIK3CA (0.67) | FYNPIK3CAATRPIK3CDPIK3CB | |
| SCHEMBL4065810 | 0.81 | PIK3CA (0.61) | FYNPIK3CAATRPIK3CDPIK3CB | |
| SCHEMBL4054806 | 0.81 | PIK3CA (0.63) | FYNPIK3CAATRPIK3CDPIK3CB | |
| SCHEMBL4381808 | 0.81 | PIK3CD (0.51) | FYNPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3514614 | 0.80 | FYN (0.64) | FYNPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4054305 | 0.79 | PIK3CA (0.61) | FYNPIK3CAATRPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318410-A1 | IMIDAZOPYRIDAZINES AS LIPID KINASE INHIBITORS | NOVARTIS AG | 2009-12-24 | — | — | US | claimed |
| CN-101528748-A | Imidazopyridazines as PI3K lipid kinase inhibitors | NOVARTIS AG (CH) | 2009-09-09 | — | — | CN | claimed |
| EP-2079744-A1 | IMIDAZOPYRIDAZINES AS PI3K LIPID KINASE INHIBITORS | Novartis AG (CH) | 2009-07-22 | — | — | EP | claimed |
| EP-1972631-A1 | Imidazopyridazines as PI3K lipid kinase inhibitors | Novartis AG (CH) | 2008-09-24 | — | — | EP | claimed |
| WO-2008052733-A1 | IMIDAZOPYRIDAZINES AS PI3K LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-05-08 | — | — | WO | claimed |
| US-20090318410-A1 | IMIDAZOPYRIDAZINES AS LIPID KINASE INHIBITORS | NOVARTIS AG | 2009-12-24 | — | — | US | disclosed |
| EP-1972631-A1 | Imidazopyridazines as PI3K lipid kinase inhibitors | Novartis AG (CH) | 2008-09-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318410-A1 | IMIDAZOPYRIDAZINES AS LIPID KINASE INHIBITORS | PI4KA, PIK3CA, PIK3CB | FYN 492/4885PIK3CA 2/4885ATR 1178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.