Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.70 |
| ▸ | AURKA | O14965 | 4/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059350 | 0.92 | SYK (0.73) | SYKAURKAAURKB | |
| SCHEMBL4069027 | 0.91 | SYK (0.70) | SYKAURKAAURKB | |
| SCHEMBL4061421 | 0.90 | SYK (0.69) | SYKAURKAAURKB | |
| SCHEMBL4064181 | 0.90 | SYK (0.71) | SYKAURKAAURKB | |
| SCHEMBL4060814 | 0.87 | SYK (0.79) | SYKAURKAAURKB | |
| SCHEMBL4055250 | 0.86 | SYK (0.69) | SYKAURKAAURKB | |
| SCHEMBL4056284 | 0.85 | SYK (0.67) | SYKAURKAAURKB | |
| SCHEMBL4060190 | 0.85 | SYK (0.73) | SYKAURKAAURKB | |
| SCHEMBL4059455 | 0.83 | SYK (0.74) | SYKAURKAAURKB | |
| SCHEMBL4059448 | 0.83 | SYK (0.76) | SYKAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794148-B1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-04-15 | — | — | EP | claimed |