Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 15/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065949 | 0.99 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3KDM4ECYP2D6 | |
| SCHEMBL4057977 | 0.99 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3KDM4ECYP2D6 | |
| SCHEMBL4945756 | 0.89 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3KDM4ECYP2D6 | |
| SCHEMBL4058148 | 0.88 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3KDM4EKCNH2 | |
| Hydrochloric Acid SCHEMBL4944139 | 0.88 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3KDM4ELMNA | |
| SCHEMBL4063394 | 0.88 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3KDM4ECYP2D6 | |
| Hydrochloric Acid SCHEMBL4945029 | 0.87 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL4945777 | 0.87 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3KDM4ECYP2D6 | |
| SCHEMBL4059609 | 0.85 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3KDM4ECYP2D6 | |
| SCHEMBL4063157 | 0.84 | SLC6A2 (0.69) | SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |