Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TYK2 | P29597 | 11/20 | 0.48 |
| ▸ | JAK2 | O60674 | 8/20 | 0.48 |
| ▸ | JAK1 | P23458 | 5/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061085 | 0.92 | POLB (0.50) | POLBTYK2ABL1SRCGRM8 | |
| SCHEMBL4061697 | 0.87 | GRM8 (0.55) | POLBTYK2JAK2JAK1GRM8 | |
| SCHEMBL4061467 | 0.84 | POLB (0.53) | POLBTYK2JAK2JAK1ABL1 | |
| SCHEMBL4060750 | 0.82 | POLB (0.50) | POLBTYK2JAK2JAK1ABL1 | |
| SCHEMBL4060887 | 0.81 | POLB (0.49) | POLBGRM8GRM7GRM4 | |
| SCHEMBL4062838 | 0.81 | MAPT (0.56) | POLBTYK2JAK2JAK1GRM8 | |
| SCHEMBL4061768 | 0.80 | HTR2C (0.62) | — | |
| SCHEMBL4058614 | 0.79 | GRM8 (0.53) | POLBGRM8GRM7GRM4 | |
| SCHEMBL4062046 | 0.77 | MAPT (0.54) | POLB | |
| SCHEMBL4060261 | 0.76 | POLB (0.48) | POLBTYK2JAK2JAK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |