Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 5/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057918 | 0.89 | ITK (0.47) | MAP4K1MAP2K4MAPK14ITKPIM1 | |
| SCHEMBL4068311 | 0.88 | ITK (0.46) | MAP4K1MAP2K4MAPK14ITKKDR | |
| SCHEMBL4061642 | 0.86 | MAP2K4 (0.43) | MAP2K4MAPK14ITKPIM1LRRK2 | |
| SCHEMBL4065232 | 0.85 | MAP2K4 (0.48) | MAP2K4MAPK14ITKLRRK2TRPA1 | |
| SCHEMBL4063919 | 0.84 | MAP2K4 (0.50) | MAP2K4MAPK14ITKLRRK2TRPA1 | |
| SCHEMBL4060966 | 0.84 | MAP2K4 (0.41) | MAP2K4ITKPIM1LRRK2TRPA1 | |
| SCHEMBL4059673 | 0.84 | MAP2K4 (0.62) | MAP4K1MAP2K4MAPK14ITKLRRK2 | |
| SCHEMBL4060839 | 0.83 | ITK (0.48) | MAP4K1MAP2K4MAPK14ITKPIM1 | |
| SCHEMBL4061854 | 0.82 | MAP2K4 (0.48) | MAP2K4MAPK14ITKLRRK2KDR | |
| SCHEMBL4059067 | 0.82 | MAP2K4 (0.50) | MAP2K4MAPK14ITKLRRK2TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7495015-B2 | Indazole derivatives and methods for using the same | ROCHE PALO ALTO LLC (US) | 2009-02-24 | — | — | US | claimed |
| EP-1747202-A1 | INDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F.HOFFMANN-LA ROCHE AG (CH) | 2007-01-31 | — | — | EP | claimed |
| US-20050215595-A1 | Indazole derivatives and methods for using the same | ROCHE PALO ALTO LLC | 2005-09-29 | — | — | US | claimed |
| WO-2005085206-A1 | INDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-15 | — | — | WO | claimed |
| US-7495015-B2 | Indazole derivatives and methods for using the same | ROCHE PALO ALTO LLC (US) | 2009-02-24 | — | — | US | disclosed |
| US-7495015-B2 | Indazole derivatives and methods for using the same | ROCHE PALO ALTO LLC (US) | 2009-02-24 | — | — | US | disclosed |
| US-7495015-B2 | Indazole derivatives and methods for using the same | ROCHE PALO ALTO LLC (US) | 2009-02-24 | — | — | US | disclosed |
| US-20050215595-A1 | Indazole derivatives and methods for using the same | ROCHE PALO ALTO LLC | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215595-A1 | Indazole derivatives and methods for using the same | MAPK1, MAP3K1, MAP3K7 | MAP4K1 30/4885MAP2K4 73/4885MAPK14 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.