Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 8/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 4/20 | 0.43 |
| ▸ | LAP3 | P28838 | 3/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.43 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169670 | 1.00 | CCR1 (0.61) | CCR1KDM4EMAPTRENLAP3 | |
| SCHEMBL4064275 | 0.91 | CCR1 (0.58) | CCR1RENLAP3ANPEPRNPEP | |
| SCHEMBL6832278 | 0.91 | CCR1 (0.58) | CCR1RENLAP3ANPEPRNPEP | |
| SCHEMBL7591156 | 0.89 | CCR1 (0.61) | CCR1RENLAP3ANPEPRNPEP | |
| SCHEMBL4058726 | 0.89 | CCR1 (0.50) | CCR1RENLAP3ANPEPRNPEP | |
| SCHEMBL6675017 | 0.89 | CCR1 (0.61) | CCR1RENLAP3ANPEPRNPEP | |
| Hydroxyamine SCHEMBL6688642 | 0.89 | CCR1 (0.57) | CCR1RENLAP3ANPEPRNPEP | |
| SCHEMBL6167499 | 0.87 | CCR1 (0.57) | CCR1RENLAP3ANPEPRNPEP | |
| SCHEMBL4066974 | 0.85 | CCR1 (0.49) | CCR1RENLAP3ANPEPRNPEP | |
| SCHEMBL4068003 | 0.84 | CCR1 (0.58) | CCR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | disclosed |