Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 4/20 | 0.52 |
| ▸ | FLT3 | P36888 | 3/20 | 0.52 |
| ▸ | MERTK | Q12866 | 3/20 | 0.52 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | F2R | P25116 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 4/20 | 0.43 |
| ▸ | CCND1 | P24385 | 4/20 | 0.43 |
| ▸ | CCND2 | P30279 | 3/20 | 0.43 |
| ▸ | CCND3 | P30281 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064070 | 0.89 | TYRO3 (0.53) | TYRO3FLT3MERTKGAS6SYK | |
| SCHEMBL14658789 | 0.76 | NPY5R (0.57) | TYRO3SYKCTSKMAPK8 | |
| SCHEMBL4070567 | 0.74 | CDK4 (0.51) | FLT3SYKCDK4CCND1CCND3 | |
| SCHEMBL26941974 | 0.73 | CDK2 (0.61) | TYRO3FLT3MERTKGAS6AXL | |
| SCHEMBL21596335 | 0.72 | MAPK3 (0.54) | — | |
| SCHEMBL26762362 | 0.71 | MAPK8 (0.61) | TYRO3FLT3MERTKGAS6AXL | |
| SCHEMBL4072083 | 0.71 | CDK4 (0.56) | FLT3SYKCDK4CCND1CCND2 | |
| SCHEMBL23262220 | 0.71 | PRKCQ (0.51) | TYRO3FLT3MERTKGAS6AXL | |
| SCHEMBL4071098 | 0.71 | SYK (0.49) | SYKCDK4CCND1CCND2CCND3 | |
| SCHEMBL14657206 | 0.70 | MAPK8 (0.64) | TYRO3FLT3MERTKGAS6AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590341-B1 | 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2009-06-17 | — | — | EP | claimed |