Sugi Predict

Sugi Predict / Compounds / Carbamic Acid

Carbamic Acid

Carbamic Acid

SCHEMBL4064213

NC(=O)O.Nc1ncnn2c(C3CCCCC3)nc(-c3ccc4ccc(-c5cccs5)nc4c3)c12

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 6/20 0.69
▸ INSR P06213 3/20 0.57
▸ TNK2 Q07912 14/20 0.54
▸ CYP3A4 P08684 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4065306 0.94 IGF1R (0.65) IGF1RINSRTNK2CYP3A4
SCHEMBL402049 0.93 IGF1R (0.77) IGF1RINSRTNK2CYP3A4
SCHEMBL400198 0.90 IGF1R (0.61) IGF1RINSRTNK2CYP3A4
Carbamic Acid SCHEMBL4070437 0.89 IGF1R (0.86) IGF1RINSRTNK2CYP3A4
SCHEMBL402380 0.86 IGF1R (0.58) IGF1RINSRTNK2
SCHEMBL397531 0.86 IGF1R (0.61) IGF1RINSRTNK2CYP3A4
Carbamic Acid SCHEMBL4069747 0.85 IGF1R (0.69) IGF1RINSRTNK2CYP3A4
SCHEMBL402150 0.85 IGF1R (0.63) IGF1RINSRTNK2CYP3A4
SCHEMBL4073360 0.83 IGF1R (0.81) IGF1RINSRTNK2CYP3A4
SCHEMBL399400 0.82 IGF1R (1.00) IGF1RINSRTNK2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2168968-B1 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors OSI PHARMACEUTICALS LLC (US) 2017-08-23 — — EP claimed
EP-1740591-B1 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS OSI PHARM INC (US) 2009-06-17 — — EP claimed