Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | KDM6A | O15550 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692888 | 0.80 | MEN1 (0.60) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL29931105 | 0.80 | MEN1 (0.60) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL4001170 | 0.80 | NPC1 (0.49) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL27784903 | 0.79 | MEN1 (0.58) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL12076627 | 0.79 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL2800895 | 0.78 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL16581490 | 0.77 | KDM4E (0.60) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL27029799 | 0.76 | TOP2A (0.50) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL3475375 | 0.76 | NPC1 (0.58) | KDM4EALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL171055 | 0.76 | TOP2A (0.62) | KDM4EALDH1A1HSD17B10HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151546-A2 | METHODS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2009-12-17 | — | — | WO | claimed |