SCHEMBL4064557 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	KDR	P35968	12/20	0.40

▸	FGFR1	P11362	6/20	0.37

▸	PLK4	O00444	2/20	0.37

▸	AURKA	O14965	2/20	0.37

▸	MAP4K4	O95819	2/20	0.37

▸	PAK4	O96013	2/20	0.37

▸	ABL1	P00519	2/20	0.37

▸	LCK	P06239	2/20	0.37

▸	CSF1R	P07333	2/20	0.37

▸	RET	P07949	2/20	0.37

▸	MET	P08581	2/20	0.37

▸	PDGFRB	P09619	2/20	0.37

▸	KIT	P10721	2/20	0.37

▸	PDGFRA	P16234	2/20	0.37

▸	FLT1	P17948	2/20	0.37

▸	FGFR3	P22607	2/20	0.37

▸	TYK2	P29597	2/20	0.37

▸	AXL	P30530	2/20	0.37

▸	FLT4	P35916	2/20	0.37

▸	BLK	P51451	2/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4061934	1.00	KDR (0.40)	KDRFGFR1PLK4AURKAMAP4K4
SCHEMBL4064558	1.00	KDR (0.40)	KDRFGFR1PLK4AURKAMAP4K4
SCHEMBL4061938	1.00	KDR (0.40)	KDRFGFR1PLK4AURKAMAP4K4
SCHEMBL4485148	0.89	KDR (0.47)	KDRFGFR1PLK4AURKAMAP4K4
SCHEMBL4485143	0.88	KDR (0.40)	KDRFGFR1PLK4AURKAMAP4K4
SCHEMBL4485145	0.88	KDR (0.40)	KDRFGFR1PLK4AURKAMAP4K4
SCHEMBL4058955	0.88	KDR (0.47)	KDRFGFR1PLK4AURKAMAP4K4
SCHEMBL4058951	0.88	KDR (0.40)	KDRFGFR1PLK4AURKAMAP4K4
SCHEMBL4061588	0.88	KDR (0.39)	KDRFGFR1PLK4AURKAMAP4K4
SCHEMBL4061591	0.88	KDR (0.39)	KDRFGFR1PLK4AURKAMAP4K4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2009036066-A1	VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY	CURIS, INC. (US)	2009-03-19	—	—	WO	disclosed