(+)-Tranylcypromine

(+)-Tranylcypromine

SCHEMBL40651

NC1CC1c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MAOAMAOB

The experimentally established mechanism targets of (+)-Tranylcypromine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB known ✓ P27338 11/20 1.00
MAOA known ✓ P21397 7/20 1.00
KDM1A O60341 14/20 1.00
CYP2C19 P33261 4/20 1.00
CYP2B6 P20813 3/20 1.00
KCNH2 Q12809 3/20 1.00
RCOR1 Q9UKL0 3/20 1.00
CYP1A2 P05177 2/20 1.00
CYP2D6 P10635 2/20 1.00
CYP2C9 P11712 2/20 1.00
LMNA P02545 2/20 1.00
TAAR1 Q96RJ0 2/20 1.00
CYP3A4 P08684 1/20 1.00
HTR1A P08908 1/20 1.00
ADRA2A P08913 1/20 1.00
CYP2A6 P11509 1/20 1.00
SLC6A2 P23975 1/20 1.00
HTR2C P28335 1/20 1.00
ADRA1A P35348 1/20 1.00
DRD3 P35462 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(+)-Tranylcypromine SCHEMBL145650 1.00 KDM1A (1.00) KDM1AMAOBMAOACYP2C19CYP2B6
(+)-Tranylcypromine SCHEMBL3406205 1.00 KDM1A (1.00) KDM1AMAOBMAOACYP2C19CYP2B6
(+)-Tranylcypromine SCHEMBL29360959 1.00 KDM1A (1.00) KDM1AMAOBMAOACYP2C19CYP2B6
(+)-Tranylcypromine SCHEMBL13764364 1.00 KDM1A (1.00) KDM1AMAOBMAOACYP2C19CYP2B6
(+)-Tranylcypromine SCHEMBL13785162 1.00 KDM1A (1.00) KDM1AMAOBMAOACYP2C19CYP2B6
(+)-Tranylcypromine SCHEMBL34339 1.00 KDM1A (1.00) KDM1AMAOBMAOACYP2C19CYP2B6
(+)-Tranylcypromine SCHEMBL1649712 1.00 KDM1A (1.00) KDM1AMAOBMAOACYP2C19CYP2B6
(+)-Tranylcypromine SCHEMBL4740285 1.00 KDM1A (1.00) KDM1AMAOBMAOACYP2C19CYP2B6
(+)-Tranylcypromine SCHEMBL1720497 1.00 KDM1A (1.00) KDM1AMAOBMAOACYP2C19CYP2B6
(+)-Tranylcypromine SCHEMBL2755938 1.00 KDM1A (1.00) KDM1AMAOBMAOACYP2C19CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5394 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-224290539-U Perovskite solar cell module Liyuan New Energy Technology (Wuxi) Co.,Ltd. (CN) 2026-05-26 CN claimed
EP-4724119-A2 LIVER SUPPORT SYSTEMS AND METHODS OF USE Kanto Biomedicines, Inc. (US) 2026-04-15 EP claimed
US-12565680-B2 Cancer neoantigens and their utilities in cancer vaccines and TCR-based cancer immunotherapy THE METHODIST HOSPITAL SYSTEM (US) 2026-03-03 US claimed
EP-3784232-B1 IMPROVED METHODS FOR INDUCING TISSUE REGENERATION AND SENOLYSIS IN MAMMALIAN CELLS AGEX THERAPEUTICS INC (US) 2026-02-11 EP claimed
EP-3931189-B1 AZEPINO-INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS UNIV CALIFORNIA (US) 2025-12-24 EP claimed
WO-2025235516-A1 DEVELOPMENT OF LYSINE-SPECIFIC DEMETHYLASE 1 (LSD1) INHIBITORS AS ANTI-CANCER REAGENTS THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS (US) 2025-11-13 WO claimed
US-20250339483-A1 EXTRACELLULAR VESICLES FROM MICROALGAE, THEIR BIODISTRIBUTION UPON INTRANASAL ADMINISTRATION, AND USES THEREOF AGS THERAPEUTICS SAS (FR) 2025-11-06 US claimed
EP-4608424-A1 EXTRACELLULAR VESICLES FROM MICROALGAE, THEIR BIODISTRIBUTION UPON INTRANASAL ADMINISTRATION, AND USES THEREOF AGS Therapeutics SAS (FR) 2025-09-03 EP claimed
WO-2025106897-A1 METHODS AND COMPOSITIONS FOR CREATING INDUCED PLURIPOTENT STEM CELLS COLOSSAL BIOSCIENCES INC. (US) 2025-05-22 WO claimed
CN-119968006-A Perovskite battery component and preparation method thereof 深圳市光因科技有限公司 2025-05-09 CN claimed
EP-0635508-A1 TETRAHYDROPYRIDINE DERIVATIVE HAVING SUBSTITUENTS ON THREE RINGS Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1995-01-25 EP claimed
US-5340838-A Administering serotonin agonist to mammals ELI LILLY AND COMPANY (US) 1994-08-23 US claimed
EP-0455510-A2 Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion ELI LILLY AND COMPANY (US) 1991-11-06 EP claimed
EP-0440704-A1 COMPOSITIONS FOR TREATING TOBACCO WITHDRAWEL SYMPTOMS. MASSACHUSETTS INST TECHNOLOGY (US) 1991-08-14 EP claimed
US-4977145-A ADMINISTERING ANGIOTENSIN CONVERTING ENZYME INHIBITOR AND ANTIDEPRESSANT E. R. SQUIBB & SONS, INC. (US) 1990-12-11 US claimed
WO-1990004387-A2 COMPOSITIONS FOR TREATING TOBACCO WITHDRAWAL SYMPTOMS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1990-05-03 WO claimed
EP-0035597-B1 PHARMACEUTICAL PREPARATIONS Röhm Pharma GmbH (DE) 1984-08-01 EP claimed
US-4331687-A /+/TRANS-2-PHENYLCYCLOPROPYLAMINE; ANTIDEPRESSANTS ROHM PHARMA GMBH (DE) 1982-05-25 US claimed
EP-0035597-A2 Pharmaceutical preparations Röhm Pharma GmbH (DE) 1981-09-16 EP claimed
US-3961073-A 2-PHENYL-CYCLOPROPYLAMINE NELSON RESEARCH & DEVELOPMENT COMPANY (US) 1976-06-01 US claimed