SCHEMBL4065429

SCHEMBL4065429

O=C(c1ccc(Nc2nccc(-c3ccc(Cl)cc3)n2)cc1)N1C[CH]NCC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IKBKB O14920 7/20 0.54
CHUK O15111 6/20 0.54
PIK3CA P42336 2/20 0.51
PIK3CB P42338 2/20 0.51
PIK3CG P48736 2/20 0.51
JAK2 O60674 3/20 0.48
CAMK2D Q13557 4/20 0.47
JAK3 P52333 2/20 0.47
HDAC3 O15379 1/20 0.47
NCOR1 O75376 1/20 0.47
JAK1 P23458 1/20 0.47
TYK2 P29597 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
MAPK8 P45983 1/20 0.46
MAPK10 P53779 1/20 0.46
CLK1 P49759 1/20 0.45
DYRK1A Q13627 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3048434 0.88 IKBKB (0.66) IKBKBCHUKPIK3CAPIK3CBPIK3CG
SCHEMBL14021219 0.85 PIK3CA (0.58) IKBKBCHUKPIK3CAPIK3CBPIK3CG
SCHEMBL8314676 0.85 IKBKB (0.54) IKBKBCHUKPIK3CAPIK3CBPIK3CG
SCHEMBL14021236 0.84 PIK3CA (0.53) IKBKBCHUKPIK3CAPIK3CBPIK3CG
SCHEMBL14021190 0.84 MTOR (0.60) IKBKBCHUKPIK3CAPIK3CBPIK3CG
SCHEMBL11924733 0.84 MTOR (0.60) IKBKBCHUKPIK3CAPIK3CBPIK3CG
SCHEMBL14021271 0.83 IKBKB (0.55) IKBKBCHUKPIK3CAPIK3CBPIK3CG
SCHEMBL14021276 0.83 IKBKB (0.55) IKBKBCHUKPIK3CAPIK3CBPIK3CG
SCHEMBL14021274 0.83 IKBKB (0.55) IKBKBCHUKPIK3CAPIK3CBPIK3CG
SCHEMBL7020880 0.83 PIK3CA (0.56) IKBKBCHUKPIK3CAPIK3CBPIK3CG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1349840-B1 ANILINOPYRIMIDINE DERIVATIVES AS JNK PATHWAY INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO SIGNAL PHARM LLC (US) 2009-03-11 EP disclosed
EP-1608375-A1 METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK Signal Pharmaceuticals LLC (US) 2005-12-28 EP disclosed
WO-2004084901-A1 METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK SIGNAL PHARMACEUTICALS, LLC (US) 2004-10-07 WO disclosed
EP-1349840-A2 ANILINOPYRIMIDINE DERIVATIVES AS JNK PATHWAY INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO SIGNAL PHARMACEUTICALS, INC. (US) 2003-10-08 EP disclosed
EP-1349841-A2 ANILINOPYRIMIDINE DERIVATIVES AS IKK INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO SIGNAL PHARMACEUTICALS, INC. (US) 2003-10-08 EP disclosed
WO-2002046171-A2 ANILINOPYRIMIDINE DERIVATIVES AS IKK INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO SIGNAL PHARMACEUTICALS, INC. (US) 2002-06-13 WO disclosed
WO-2002046170-A2 ANILINOPYRIMIDINE DERIVATIVES AS JNK PATHWAY INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO SIGNAL PHARMACEUTICALS, INC. (US) 2002-06-13 WO disclosed