Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL401954 | 0.91 | KDM4E (0.31) | KDM4ENPC1ALDH1A1RAB9AHSD17B10 | |
| SCHEMBL4068559 | 0.88 | — | — | |
| SCHEMBL399693 | 0.87 | KDM4E (0.35) | KDM4ENPC1ALDH1A1RAB9AHSD17B10 | |
| SCHEMBL4063195 | 0.87 | — | — | |
| SCHEMBL399767 | 0.85 | — | — | |
| SCHEMBL4074225 | 0.82 | — | — | |
| SCHEMBL4066073 | 0.81 | — | — | |
| SCHEMBL4063671 | 0.80 | — | — | |
| SCHEMBL4061865 | 0.80 | KDM4E (0.32) | KDM4ENPC1ALDH1A1RAB9AHSD17B10 | |
| SCHEMBL400240 | 0.79 | IGF1R (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-B1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARM INC (US) | 2009-06-17 | — | — | EP | claimed |