SCHEMBL4066186

SCHEMBL4066186

NC1=CCc2ccccc2[CH]1

nearest known ligand 0.41

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
HTR6 P50406 1/20 0.34
IDO1 P14902 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11338712 0.80 CA1 (0.53) CA1CA2HTR6IDO1
SCHEMBL3348711 0.73 CA1 (0.41) CA1CA2
SCHEMBL4311972 0.73 CA1 (0.41) CA1CA2
SCHEMBL1923119 0.73 CA1 (0.46) CA1CA2
SCHEMBL1958676 0.73 CA1 (0.41) CA1CA2
SCHEMBL4754304 0.73 CA1 (0.41) CA1CA2
SCHEMBL4309882 0.70 CA1 (0.36) CA1CA2
SCHEMBL853163 0.70 CA1 (0.39) CA1CA2
SCHEMBL5022550 0.68 CA1 (0.38) CA1CA2HTR6
SCHEMBL7190108 0.68 CA1 (0.38) CA1CA2HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1028945-B9 SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS AMGEN INC (US) 2009-02-18 EP disclosed
EP-1625207-A4 COMPOUNDS FOR TREATMENT OF INFLAMMATION, DIABETES AND RELATED DISORDERS THERACOS INC (US) 2008-11-12 EP disclosed
EP-1882694-A1 THIOPHENE COMPOUND HAVING PHOSPHORIC ESTER AND PROCESS FOR PRODUCING THE SAME Nissan Chemical Industries, Ltd. (JP) 2008-01-30 EP disclosed
EP-1028945-B1 SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS AMGEN INC (US) 2007-07-11 EP disclosed
EP-1625207-A2 COMPOUNDS FOR TREATMENT OF INFLAMMATION, DIABETES AND RELATED DISORDERS Theracos, Inc. (US) 2006-02-15 EP disclosed
WO-2004101752-A2 COMPOUNDS FOR TREATMENT OF INFLAMMATION, DIABETES AND RELATED DISORDERS THERACOS, INC. (US) 2004-11-25 WO disclosed
EP-1448564-A2 SUBSTITUTED INDOLIZINE-LIKE COMPOUNDS AND METHODS OF USE Amgen Inc. (US) 2004-08-25 EP disclosed
WO-2003044021-A2 SUBSTITUTED INDOLIZINE-LIKE COMPOUNDS AND METHODS OF USE AMGEN INC. (US) 2003-05-30 WO disclosed
EP-1042293-A1 SUBSTITUTED PYRIDINE AND PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USE Amgen Inc. (US) 2000-10-11 EP disclosed
EP-1037881-A1 PROCESS OF PREPARING SUBSTITUTED PYRIMIDINONES Amgen Inc. (US) 2000-09-27 EP disclosed
EP-1028945-A1 SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS Amgen Inc. (US) 2000-08-23 EP disclosed
US-6045974-A ADDITION PHOTOPOLYMERIZATION OF NONVOLATILE MONOMERIC, OLIGOMERIC OR POLYMERIC COMPOUNDS CONTAINING AT LEAST ONE ETHYLENICALLY UNSATURATED DOUBLE BOND CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-04-04 US disclosed
EP-0948496-A2 SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE Amgen inc. (US) 1999-10-13 EP disclosed
EP-0948497-A2 SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE Amgen inc. (US) 1999-10-13 EP disclosed
WO-1999032448-A1 SUBSTITUTED PYRIDINE AND PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USE AMGEN INC. (US) 1999-07-01 WO disclosed
WO-1999028303-A1 PROCESS OF PREPARING SUBSTITUTED PYRIMIDINONES AMGEN, INC. (US) 1999-06-10 WO disclosed
WO-1999024404-A1 SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS AMGEN INC. (US) 1999-05-20 WO disclosed
WO-1998024780-A2 SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE AMGEN INC. (US) 1998-06-11 WO disclosed
WO-1998024782-A2 SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AMGEN INC. (US) 1998-06-11 WO disclosed
EP-0109291-A1 Photopolymerizable composition FUJI PHOTO FILM CO., LTD. (JP) 1984-05-23 EP disclosed