SCHEMBL4066313

SCHEMBL4066313

CN1CCN(c2cc(-c3ccc(-c4ccccn4)s3)ncn2)CC1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 3/20 0.61
CYP1A2 P05177 6/20 0.57
CYP2C19 P33261 2/20 0.56
ALOX15 P16050 2/20 0.56
ALDH1A1 P00352 4/20 0.50
HSD17B10 Q99714 2/20 0.50
KDM4E B2RXH2 2/20 0.50
GLA P06280 2/20 0.50
MAPT P10636 2/20 0.50
HPGD P15428 1/20 0.50
NPC1 O15118 2/20 0.49
RAB9A P51151 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.48
HTR3A P46098 1/20 0.48
TSHR P16473 2/20 0.46
CYP2C9 P11712 1/20 0.46
MAPK1 P28482 1/20 0.46
HTR6 P50406 1/20 0.46
METAP1 P53582 1/20 0.45
LRRK2 Q5S007 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2385543 0.79 HRH4 (0.63) HRH4CYP1A2CYP2C19ALOX15ALDH1A1
SCHEMBL2385078 0.79 HRH4 (0.51) HRH4ALDH1A1KDM4EGLAMAPT
Hydrochloric Acid SCHEMBL11785742 0.75 HRH4 (0.97) HRH4CYP1A2CYP2C19ALOX15ALDH1A1
SCHEMBL2388209 0.74 HRH4 (0.58) HRH4CYP1A2CYP2C19ALOX15ALDH1A1
SCHEMBL4057085 0.73 CYP1A2 (0.72) HRH4CYP1A2CYP2C19ALOX15ALDH1A1
SCHEMBL24319168 0.72 HRH4 (0.65) HRH4CYP1A2CYP2C19ALOX15ALDH1A1
SCHEMBL29904791 0.70 PLD1 (0.61) HRH4ALDH1A1HSD17B10KDM4EMAPT
SCHEMBL159733 0.70 PLD1 (0.61) HRH4ALDH1A1HSD17B10KDM4EMAPT
SCHEMBL17754138 0.70 HRH4 (0.51) HRH4CYP1A2CYP2C19ALOX15NPC1
SCHEMBL2384719 0.70 HRH4 (0.59) HRH4ALDH1A1KDM4EGLASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009035671-A1 SUBSTITUTED NITROGEN-CONTAINING HETEROARYL DERIVATIVES USEFUL AS MODULATORS OF THE HISTAMINE H4 RECEPTOR JANSSEN PHARMACEUTICA N.V. (BE) 2009-03-19 WO disclosed