Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.37 |
| ▸ | MTOR | P42345 | 4/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL189969 | 0.82 | PIK3CA (0.52) | HTR2CPIK3CAMTOR | |
| Hydrochloric Acid SCHEMBL30151154 | 0.81 | PIK3CA (0.51) | HTR2CPIK3CAMTOR | |
| SCHEMBL4069888 | 0.81 | HTR2C (0.51) | HTR2CGUSBTSHRKMT2ANPSR1 | |
| SCHEMBL19849051 | 0.81 | SMN1; SMN2 (0.41) | PIK3CAMTORPIK3R1SMN1; SMN2MAPK1 | |
| SCHEMBL1181308 | 0.79 | SMN1; SMN2 (0.40) | PIK3CAMTORPIK3R1SMN1; SMN2MAPK1 | |
| SCHEMBL26252782 | 0.77 | SMN1; SMN2 (0.38) | PIK3CAMTORPIK3R1SMN1; SMN2MAPK1 | |
| SCHEMBL27943079 | 0.77 | PIK3CA (0.39) | PIK3CAMTORPIK3R1SMN1; SMN2MAPK1 | |
| SCHEMBL1180546 | 0.76 | PIK3CA (0.47) | PIK3CAMTORPIK3R1SMN1; SMN2MAPK1 | |
| SCHEMBL190265 | 0.76 | PIK3CA (0.40) | PIK3CAMTORPIK3R1SMN1; SMN2MAPK1 | |
| SCHEMBL29788273 | 0.76 | PIK3CA (0.40) | PIK3CAMTORPIK3R1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114949-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| EP-2032582-A1 | PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-11 | — | — | EP | disclosed |
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |
| WO-2007122410-A1 | PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-11-01 | — | — | WO | disclosed |
| EP-1812445-A1 | PHARMACEUTICAL COMPOUNDS | Piramed Limited (GB) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006046031-A1 | PHARMACEUTICAL COMPOUNDS | PIRAMED LIMITED (GB) | 2006-05-04 | — | — | WO | disclosed |