Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | CDK1 | P06493 | 2/20 | 0.59 |
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.59 |
| ▸ | CDK7 | P50613 | 1/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.59 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.59 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.59 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.59 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.59 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.59 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.59 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.59 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.59 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060323 | 0.93 | CDK1 (0.69) | GSK3BCDK1CDK2DYRK3CDK7 | |
| Hydrochloric Acid SCHEMBL3191903 | 0.86 | CDK7 (0.68) | GSK3BCDK1CDK2DYRK3CDK7 | |
| Hydrochloric Acid SCHEMBL3198965 | 0.83 | CDK7 (0.66) | GSK3BCDK1CDK2DYRK3CDK7 | |
| SCHEMBL4059903 | 0.82 | CDK7 (0.76) | GSK3BCDK1CDK2DYRK3CDK7 | |
| SCHEMBL4025806 | 0.82 | CDK7 (0.85) | GSK3BCDK1CDK2DYRK3CDK7 | |
| Hydrochloric Acid SCHEMBL4058368 | 0.81 | CDK7 (0.84) | GSK3BCDK1CDK2DYRK3CDK7 | |
| SCHEMBL4016405 | 0.80 | CDK7 (0.83) | GSK3BCDK1CDK2DYRK3CDK7 | |
| SCHEMBL4062352 | 0.80 | CDK7 (0.83) | GSK3BCDK1CDK2DYRK3CDK7 | |
| SCHEMBL4059588 | 0.80 | GSK3B (0.68) | GSK3BCDK1CDK2DYRK3CDK7 | |
| SCHEMBL4019774 | 0.80 | CDK7 (0.82) | GSK3BCDK1CDK2DYRK3CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-B9 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | disclosed |
| EP-1492785-B1 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-03 | — | — | EP | disclosed |