Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.53 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 8/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3992075 | 0.87 | MAPK14 (0.51) | MAPK14BRAFTDP1MEN1KMT2A | |
| SCHEMBL4068114 | 0.86 | MAPK14 (0.43) | MAPK14ABCC8KCNJ11ATMTDP1 | |
| SCHEMBL3992567 | 0.81 | MAPK14 (0.45) | MAPK14BRAFTDP1MEN1KMT2A | |
| SCHEMBL4122831 | 0.77 | MAPT (0.43) | MAPK14BRAFKMT2A | |
| SCHEMBL4066421 | 0.75 | MAPK14 (0.44) | MAPK14BRAF | |
| SCHEMBL4067103 | 0.75 | MAPK14 (0.40) | MAPK14BRAFTDP1MEN1KMT2A | |
| SCHEMBL4063899 | 0.74 | MAPK14 (0.54) | MAPK14TDP1MEN1KMT2A | |
| SCHEMBL4071112 | 0.73 | CSNK1A1 (0.43) | MAPK14BRAFJAK2 | |
| SCHEMBL3991522 | 0.72 | BRAF (0.45) | MAPK14BRAFTDP1MEN1KMT2A | |
| SCHEMBL3997933 | 0.71 | MAPK14 (0.51) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713805-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2009-06-10 | — | — | EP | disclosed |