SCHEMBL4067544

SCHEMBL4067544

Cc1ccc(CC(=O)O)cc1OCCc1nc(-c2ccc(C(F)(F)F)cc2)oc1C(C)C

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 14/20 0.47
PPARG P37231 14/20 0.47
PPARD Q03181 10/20 0.47
PTPN1 P18031 2/20 0.42
SLC22A12 Q96S37 1/20 0.41
PSEN1 P49768 1/20 0.41
PSEN2 P49810 1/20 0.41
APH1B Q8WW43 1/20 0.41
NCSTN Q92542 1/20 0.41
APH1A Q96BI3 1/20 0.41
PSENEN Q9NZ42 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4057676 0.90 PPARA (0.43) PPARAPPARGPPARD
SCHEMBL4061500 0.89 SLC22A12 (0.44) PPARAPPARGPPARDSLC22A12
SCHEMBL4062726 0.87 PPARG (0.46) PPARAPPARGPPARDSLC22A12
SCHEMBL4061332 0.87 PPARA (0.48) PPARAPPARGPPARDPTPN1SLC22A12
SCHEMBL4065602 0.86 PPARG (0.49) PPARAPPARGPPARDPTPN1PSEN1
SCHEMBL4054612 0.85 SLC22A12 (0.44) PPARAPPARGPPARDSLC22A12
SCHEMBL4057018 0.85 PPARG (0.52) PPARAPPARGPPARD
SCHEMBL4055922 0.84 PPARG (0.43) PPARAPPARGPPARDSLC22A12
SCHEMBL4055147 0.84 PPARG (0.47) PPARAPPARGPPARDPTPN1
SCHEMBL4064587 0.83 SLC22A12 (0.39) PPARAPPARGPPARDSLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070105868-A1 Phenylacetic acid derivative, process for producing the same, and use ONO PHARMACEUTICAL CO., LTD. (JP) 2007-05-10 US claimed
EP-1666472-A1 PHENYLACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE ONO PHARMACEUTICAL CO., LTD. (JP) 2006-06-07 EP claimed
EP-1666472-B1 PHENYLACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE ONO PHARMACEUTICAL CO (JP) 2012-08-01 EP disclosed
US-7560475-B2 Phenylacetic acid derivative, process for producing the same, and use ONO PHARMACEUTICAL CO., LTD. (JP) 2009-07-14 US disclosed
US-20070105868-A1 Phenylacetic acid derivative, process for producing the same, and use ONO PHARMACEUTICAL CO., LTD. (JP) 2007-05-10 US disclosed
EP-1666472-A1 PHENYLACETIC ACID DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE ONO PHARMACEUTICAL CO., LTD. (JP) 2006-06-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070105868-A1 Phenylacetic acid derivative, process for producing the same, and use PPARA, PPARD, PPARG PPARA 1/4885PPARG 3/4885PPARD 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.