Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 5/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 14/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 14/20 | 0.49 |
| ▸ | EIF4E | P06730 | 9/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2933369 | 0.87 | ATR (0.67) | ATRMKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL2925753 | 0.86 | MKNK1 (0.64) | ATRMKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL2931547 | 0.81 | ATR (0.53) | ATRKCNH2 | |
| SCHEMBL2933269 | 0.81 | MKNK1 (0.50) | ATRMKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL2926081 | 0.79 | ATR (0.52) | ATRMKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL14269504 | 0.76 | MKNK1 (0.46) | ATRMKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL2931317 | 0.74 | MKNK1 (0.52) | ATRMKNK1MKNK2EIF4EKCNH2 | |
| SCHEMBL2927593 | 0.72 | ATR (0.46) | ATR | |
| SCHEMBL2928700 | 0.72 | ATR (0.47) | ATRMKNK1MKNK2 | |
| SCHEMBL2930914 | 0.72 | ATR (0.46) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044051-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB (publ) (SE) | 2009-04-08 | — | — | EP | claimed |
| WO-2007147874-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB (PUBL) (SE) | 2007-12-27 | — | — | WO | claimed |