SCHEMBL4068496

SCHEMBL4068496

CCCCN(C(=O)CCC)c1ccc2nc(Nc3ccc(C(C)=O)cc3)n(CCCN3CCCCC3)c2n1

nearest known ligand 0.54

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MC4R P32245 20/20 0.54
MC5R P33032 2/20 0.54
MC3R P41968 2/20 0.54
MC1R Q01726 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3814935 0.99 MC4R (0.53) MC4RMC5RMC3RMC1R
SCHEMBL13923250 0.97 MC4R (0.54) MC4RMC5RMC3RMC1R
SCHEMBL13923268 0.96 MC4R (0.54) MC4RMC5RMC3RMC1R
SCHEMBL13923247 0.94 MC4R (0.54) MC4RMC5RMC3RMC1R
SCHEMBL13923269 0.94 MC4R (0.54) MC4RMC5RMC3RMC1R
SCHEMBL13923263 0.93 MC4R (0.62) MC4RMC5RMC3RMC1R
SCHEMBL13923253 0.92 MC4R (0.52) MC4RMC5RMC3RMC1R
SCHEMBL13923257 0.90 MC4R (0.51) MC4RMC5RMC3RMC1R
SCHEMBL13923264 0.90 MC4R (0.62) MC4RMC5RMC3RMC1R
SCHEMBL4071370 0.90 MC4R (0.57) MC4RMC5RMC3RMC1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1615925-B1 IMIDAZOPYRIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS IPSEN PHARMA (FR) 2009-05-27 EP disclosed
EP-1615925-B1 IMIDAZOPYRIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS IPSEN PHARMA (FR) 2009-05-27 EP disclosed
US-7495009-B2 Imidazopyridine derivatives as melancortin receptor agonists SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2009-02-24 US disclosed
US-7495009-B2 Imidazopyridine derivatives as melancortin receptor agonists SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2009-02-24 US disclosed
EP-1615925-A1 IMIDAZOPYRIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) 2006-01-18 EP disclosed
WO-2004089951-A1 IMIDAZOPYRIDINE DERIVATIVES HAVING AN AFFINITY FOR MELANOCORTIN RECEPTORS SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2004-10-21 WO disclosed