Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434053 | 0.90 | PIK3CA (0.50) | SMN1; SMN2KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL1181730 | 0.84 | PIK3CA (0.53) | SMN1; SMN2KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL466308 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL4446531 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL13640276 | 0.81 | PIK3CA (0.52) | SMN1; SMN2PIK3CAPIK3CBHRH3 | |
| SCHEMBL4076548 | 0.80 | PIK3CA (0.60) | SMN1; SMN2PIK3CAPIK3CBPIK3R1MTOR | |
| SCHEMBL1181231 | 0.79 | PIK3CA (0.50) | SMN1; SMN2PIK3CAPIK3CBHRH3 | |
| SCHEMBL4441865 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL8199168 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL190250 | 0.79 | PIK3CA (0.50) | SMN1; SMN2PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046799-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Genentech, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | disclosed |