Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.59 |
| ▸ | AKT2 | P31751 | 19/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17644726 | 0.93 | AKT1 (0.65) | AKT1AKT2 | |
| SCHEMBL2967042 | 0.91 | AKT1 (0.61) | AKT1AKT2 | |
| SCHEMBL2968108 | 0.87 | AKT1 (0.58) | AKT1AKT2 | |
| SCHEMBL2970988 | 0.87 | AKT1 (0.68) | AKT1AKT2 | |
| SCHEMBL2969881 | 0.87 | AKT1 (0.54) | AKT1AKT2 | |
| SCHEMBL2964272 | 0.85 | AKT1 (0.52) | AKT1AKT2KCNH2 | |
| SCHEMBL3706697 | 0.85 | AKT1 (0.77) | AKT1AKT2 | |
| SCHEMBL2967050 | 0.84 | AKT1 (0.50) | AKT1AKT2KCNH2 | |
| SCHEMBL2962977 | 0.83 | AKT1 (0.71) | AKT1AKT2 | |
| SCHEMBL2979542 | 0.83 | AKT1 (0.57) | AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188291-B1 | FUSED BICYCLIC PYRIMIDINES | Bayer Pharma AG (DE) | 2012-09-19 | — | — | EP | claimed |
| EP-2050748-A1 | Novel fused pyrimidines | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-04-22 | — | — | EP | claimed |
| EP-2050748-A1 | Novel fused pyrimidines | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-04-22 | — | — | EP | disclosed |