Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 6/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063671 | 0.88 | — | — | |
| SCHEMBL4073430 | 0.87 | — | — | |
| SCHEMBL4072523 | 0.85 | KDM4E (0.38) | F2PLGPRSS1KDM4ELMNA | |
| SCHEMBL4067705 | 0.83 | — | — | |
| SCHEMBL399466 | 0.78 | PIM1 (0.32) | — | |
| SCHEMBL402077 | 0.78 | — | — | |
| SCHEMBL400475 | 0.76 | F2 (0.36) | MEN1KMT2AF2PLGPRSS1 | |
| SCHEMBL400116 | 0.75 | F2 (0.39) | MEN1KMT2AF2PLGPRSS1 | |
| SCHEMBL399525 | 0.74 | F2 (0.34) | MEN1KMT2AF2PLGPRSS1 | |
| SCHEMBL402031 | 0.74 | IGF1R (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-B1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARM INC (US) | 2009-06-17 | — | — | EP | claimed |