Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 18/20 | 0.78 |
| ▸ | EDNRB | P24530 | 14/20 | 0.78 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | DHPS | P49366 | 1/20 | 0.63 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.63 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062752 | 0.96 | EDNRA (0.84) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL4059929 | 0.88 | EDNRA (0.70) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL14289226 | 0.87 | EDNRA (0.84) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7843008 | 0.84 | EDNRA (0.68) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7843011 | 0.84 | EDNRA (0.68) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL13281278 | 0.83 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL795169 | 0.83 | EDNRA (0.88) | EDNRAEDNRB | |
| Water SCHEMBL1009968 | 0.83 | EDNRA (0.98) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL4070379 | 0.82 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL7212602 | 0.82 | EDNRA (0.92) | EDNRAEDNRBABCC3ABCC4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322624-B1 | ARYLALKANE-SULFONAMIDES HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | ACTELION PHARMACEUTICALS LTD (CH) | 2009-10-21 | — | — | EP | disclosed |
| EP-1322624-A1 | ARYLALKANE-SULFONAMIDES HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | Actelion Pharmaceuticals Ltd. (CH) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024665-A1 | ARYLALKANE-SULFONAMIDES HAVING ENDOTHELIN-ANTAGONIST ACTIVITY | ACTELION PHARMACEUTICALS LTD (CH) | 2002-03-28 | — | — | WO | disclosed |