Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 20/20 | 0.57 |
| ▸ | JAK2 | O60674 | 10/20 | 0.57 |
| ▸ | JAK1 | P23458 | 10/20 | 0.57 |
| ▸ | TYK2 | P29597 | 4/20 | 0.57 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | MARK3 | P27448 | 2/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.53 |
| ▸ | STK3 | Q13188 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.53 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.53 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.53 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.53 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066211 | 0.94 | JAK3 (0.59) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL4066792 | 0.92 | JAK3 (0.56) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL4071791 | 0.88 | JAK3 (0.56) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL4064375 | 0.87 | JAK3 (0.59) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL4065729 | 0.84 | JAK3 (0.57) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL28784031 | 0.83 | JAK3 (0.68) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL5256951 | 0.82 | JAK3 (0.67) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL5260990 | 0.82 | JAK3 (0.67) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL4071131 | 0.82 | JAK3 (0.58) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL4068619 | 0.82 | JAK3 (0.58) | JAK3JAK2JAK1TYK2PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686130-B1 | Pyrrolo[2,3-d]pyrimidine compounds as immunosuppressive agents | PFIZER PROD INC (US) | 2009-02-18 | — | — | EP | claimed |
| EP-1294724-B1 | PYRROLO¬2,3-D|PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS | PFIZER PROD INC (US) | 2006-04-19 | — | — | EP | claimed |