SCHEMBL4069685

SCHEMBL4069685

O=C(NCc1ccc(CCN(Cc2nc3ccccc3n2C(=O)O)C2CCCc3cccnc32)cc1)c1c(Cl)cncc1Cl

nearest known ligand 0.41

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 20/20 0.41
KCNH2 Q12809 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14207349 0.91 CXCR4 (0.45) CXCR4
SCHEMBL4067187 0.91 CXCR4 (0.43) CXCR4
SCHEMBL4070540 0.87 CXCR4 (0.45) CXCR4
SCHEMBL4240661 0.83 CXCR4 (0.61) CXCR4KCNH2
SCHEMBL4071638 0.83 CXCR4 (0.43) CXCR4
SCHEMBL4064229 0.83 CXCR4 (0.43) CXCR4
SCHEMBL4066740 0.81 CXCR4 (0.58) CXCR4KCNH2
SCHEMBL4061427 0.80 CXCR4 (0.41) CXCR4
SCHEMBL5053769 0.79 CXCR4 (0.43) CXCR4
SCHEMBL24825491 0.79 CXCR4 (0.48) CXCR4KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1317443-B1 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS ANORMED INC (CA) 2009-01-14 EP disclosed