Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 8/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891712 | 0.86 | KCNH2 (0.46) | SLC18A3GRIN2BCYP2D6L3MBTL1SMN1; SMN2 | |
| SCHEMBL4071530 | 0.84 | SLC18A3 (0.49) | SLC18A3GRIN2BCYP2D6CYP2C19L3MBTL1 | |
| SCHEMBL27786031 | 0.84 | SLC18A3 (0.46) | SLC18A3GRIN2BCYP2D6CYP2C19L3MBTL1 | |
| SCHEMBL15787054 | 0.80 | MEN1 (0.45) | KMT2A | |
| SCHEMBL27786027 | 0.76 | SLC18A3 (0.46) | SLC18A3GRIN2BCYP2D6CYP2C19L3MBTL1 | |
| SCHEMBL17460137 | 0.72 | SLC18A3 (0.57) | SLC18A3GRIN2BCYP2D6CYP2C19L3MBTL1 | |
| SCHEMBL27498942 | 0.71 | KCNH2 (0.52) | SLC18A3GRIN2BL3MBTL1 | |
| SCHEMBL2965273 | 0.71 | SLC18A3 (0.81) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL27786279 | 0.71 | SLC18A3 (0.55) | SLC18A3GRIN2BCYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL24291907 | 0.69 | KCNH2 (0.53) | SLC18A3GRIN2BCYP2D6SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099454-A2 | AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS | Abbott Laboratories (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008060621-A2 | AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2008-05-22 | — | — | WO | disclosed |