Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.69 |
| ▸ | CA2 | P00918 | 3/20 | 0.57 |
| ▸ | CDK2 | P24941 | 3/20 | 0.57 |
| ▸ | CDK1 | P06493 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | CDK4 | P11802 | 2/20 | 0.57 |
| ▸ | CDK7 | P50613 | 2/20 | 0.57 |
| ▸ | CDK9 | P50750 | 2/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.57 |
| ▸ | CCND1 | P24385 | 1/20 | 0.57 |
| ▸ | CCNH | P51946 | 1/20 | 0.57 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13648587 | 1.00 | SYK (0.69) | SYKCA2CDK2CDK1KDR | |
| SCHEMBL14498929 | 1.00 | SYK (0.69) | SYKCA2CDK2CDK1KDR | |
| SCHEMBL4068789 | 0.91 | SYK (0.68) | SYKCA2CDK2CDK1KDR | |
| SCHEMBL4060202 | 0.90 | SYK (0.60) | SYKCA2CDK2CDK1KDR | |
| SCHEMBL4062092 | 0.89 | SYK (0.66) | SYKCA2CDK2CDK1KDR | |
| SCHEMBL4064533 | 0.89 | SYK (0.69) | SYKCA2CDK2CDK1KDR | |
| SCHEMBL4058413 | 0.89 | SYK (0.69) | SYKCA2CDK2CDK1KDR | |
| SCHEMBL14367830 | 0.87 | SYK (0.53) | SYKKITFLT3AURKAAURKB | |
| SCHEMBL4068613 | 0.87 | SYK (0.62) | SYKCA2CDK2CDK1KDR | |
| SCHEMBL4059652 | 0.87 | SYK (0.58) | SYKCA2CDK2CDK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100480242-C | CDK-inhibiting pyrimidine compounds, method for the production thereof and use thereof as medicaments | SCHERING AG (DE) | 2009-04-22 | — | — | CN | claimed |
| EP-1392662-B1 | CDK INHIBITING PYRIMIDINES, PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BAYER SCHERING PHARMA AG (DE) | 2009-01-07 | — | — | EP | claimed |
| EP-1392662-B1 | CDK INHIBITING PYRIMIDINES, PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BAYER SCHERING PHARMA AG (DE) | 2009-01-07 | — | — | EP | disclosed |