Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 0.65 |
| ▸ | CCND1 | P24385 | 12/20 | 0.65 |
| ▸ | CDK2 | P24941 | 9/20 | 0.65 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.65 |
| ▸ | CDK1 | P06493 | 6/20 | 0.62 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.50 |
| ▸ | CCND2 | P30279 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087411 | 0.90 | CDK4 (0.80) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL4065990 | 0.82 | CDK4 (0.80) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL17293690 | 0.80 | CDK2 (0.49) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL17293717 | 0.80 | CDK2 (0.51) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL17293861 | 0.80 | CDK2 (0.49) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL4065667 | 0.80 | SYK (0.48) | CDK4CCND1CDK2ALKCCND2 | |
| SCHEMBL6088241 | 0.79 | CDK4 (1.00) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL12639355 | 0.79 | CDK4 (0.58) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL4873151 | 0.78 | CDK4 (0.68) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL4065296 | 0.78 | CDK4 (0.51) | CDK4CCND1CDK2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590341-B1 | 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1590341-A1 | 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 2005-11-02 | — | — | EP | disclosed |
| US-20040236084-A1 | E.g., 4-Cyclopentylamino-2-(5-piperazin-1-yl-pyridin-2-ylamino)-pyrimidine-5-carbonitrile; potent inhibitors of cyclin-dependent kinases useful in treating cell proliferative disorders | PFIZER INC | 2004-11-25 | — | — | US | disclosed |
| WO-2004065378-A1 | 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY LLC (US) | 2004-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236084-A1 | E.g., 4-Cyclopentylamino-2-(5-piperazin-1-yl-pyridin-2-ylamino)-pyrimidine-5-carbonitrile; potent inhibitors of cyclin-dependent kinases useful in treating cell proliferative disorders | CDK4, CCNA1, CCNI | CDK4 1/4885CCND1 11/4885CDK2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.