Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 16/20 | 0.80 |
| ▸ | IKBKB | O14920 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.57 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1926828 | 0.89 | CHEK1 (1.00) | CHEK1IKBKBMEN1KMT2AKDM4E | |
| SCHEMBL1928372 | 0.88 | CHEK1 (0.98) | CHEK1IKBKBMEN1KMT2AKDM4E | |
| SCHEMBL1928651 | 0.87 | CHEK1 (0.62) | CHEK1IKBKBMEN1KMT2AKDM4E | |
| SCHEMBL4087784 | 0.84 | CHEK1 (1.00) | CHEK1IKBKBMEN1KMT2AKDM4E | |
| SCHEMBL1929078 | 0.81 | CHEK1 (0.70) | CHEK1IKBKBMEN1KMT2AKDM4E | |
| SCHEMBL1929524 | 0.80 | CHEK1 (1.00) | CHEK1IKBKBMEN1KMT2AKDM4E | |
| SCHEMBL1928486 | 0.79 | CHEK1 (0.68) | CHEK1IKBKBMEN1KMT2AKDM4E | |
| SCHEMBL1926780 | 0.79 | CHEK1 (0.81) | CHEK1IKBKBMEN1KMT2AKDM4E | |
| SCHEMBL1928060 | 0.79 | CHEK1 (0.80) | CHEK1IKBKBMEN1KMT2AJAK2 | |
| SCHEMBL6998354 | 0.78 | KDM4E (0.80) | CHEK1IKBKBMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012166722-A1 | TREATING COLORECTAL, PANCREATIC, AND LUNG CANCER | THE GENERAL HOSPITAL CORPORATION (US) | 2012-12-06 | — | — | WO | claimed |
| WO-2012166722-A1 | TREATING COLORECTAL, PANCREATIC, AND LUNG CANCER | THE GENERAL HOSPITAL CORPORATION (US) | 2012-12-06 | — | — | WO | disclosed |
| EP-2041303-A2 | METHODS FOR CANCER TREATMENT USING TAK1 INHIBITORS | Astra Zeneca AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008007072-A2 | METHODS FOR CANCER TREATMENT USING TAK1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |