Sugi Predict

Sugi Predict / Compounds / Carbamic Acid

Carbamic Acid

Carbamic Acid

SCHEMBL4070801

Cc1cc(-c2cccs2)nc2cc(-c3nc(C4CCCCC4)n4ccnc(N)c34)ccc12.NC(=O)O

nearest known ligand 0.57

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Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 3/20 0.57
▸ CYP3A4 P08684 1/20 0.57
▸ TNK2 Q07912 16/20 0.53
▸ FGFR1 P11362 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL401395 0.94 IGF1R (0.62) IGF1RCYP3A4TNK2FGFR1
SCHEMBL400653 0.91 IGF1R (0.65) IGF1RCYP3A4TNK2FGFR1
Carbamic Acid SCHEMBL4063099 0.90 IGF1R (0.69) IGF1RCYP3A4TNK2FGFR1
Carbamic Acid SCHEMBL4069747 0.88 IGF1R (0.69) IGF1RCYP3A4TNK2FGFR1
Carbamic Acid SCHEMBL4060715 0.88 IGF1R (0.61) IGF1RCYP3A4TNK2
SCHEMBL4070080 0.86 IGF1R (0.65) IGF1RCYP3A4TNK2FGFR1
SCHEMBL397766 0.85 IGF1R (0.58) IGF1RCYP3A4TNK2FGFR1
SCHEMBL397764 0.84 IGF1R (0.60) IGF1RCYP3A4TNK2FGFR1
SCHEMBL401929 0.84 IGF1R (0.77) IGF1RCYP3A4TNK2
SCHEMBL400730 0.83 IGF1R (0.66) IGF1RCYP3A4TNK2FGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2168968-B1 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors OSI PHARMACEUTICALS LLC (US) 2017-08-23 — — EP claimed
EP-1740591-B1 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS OSI PHARM INC (US) 2009-06-17 — — EP claimed