Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.46 |
| ▸ | MTOR | P42345 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1300566 | 0.89 | PIK3CA (0.52) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL1857333 | 0.81 | PIK3CA (0.65) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL1862454 | 0.80 | PIK3CA (0.43) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL1862201 | 0.80 | PIK3CA (0.67) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL1181208 | 0.80 | PIK3CA (0.54) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL27906320 | 0.80 | PIK3CA (0.54) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL4076548 | 0.80 | PIK3CA (0.60) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL7898875 | 0.80 | PIK3CA (0.56) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21914144 | 0.79 | PIK3CA (0.51) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL2558004 | 0.79 | PIK3CA (0.51) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114949-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| EP-2046799-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Genentech, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | disclosed |