Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 5/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | FPR3 | P25089 | 1/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070949 | 1.00 | USP30 (0.51) | USP30PDE4BKDM4EMAPTTHRB | |
| SCHEMBL1019288 | 0.99 | USP30 (0.52) | USP30PDE4BKDM4EMAPTTHRB | |
| SCHEMBL1013442 | 0.99 | USP30 (0.52) | USP30PDE4BKDM4EMAPTTHRB | |
| SCHEMBL1013443 | 0.99 | USP30 (0.52) | USP30PDE4BKDM4EMAPTTHRB | |
| SCHEMBL4070951 | 0.98 | USP30 (0.51) | USP30PDE4BKDM4EMAPTTHRB | |
| SCHEMBL1015479 | 0.87 | USP30 (0.49) | USP30PDE4BKDM4EMAPTTHRB | |
| SCHEMBL2473362 | 0.87 | PDE4B (0.50) | USP30PDE4BKDM4EMAPTTHRB | |
| SCHEMBL12954779 | 0.85 | USP30 (0.48) | USP30PDE4BKDM4EMAPTTHRB | |
| SCHEMBL1018705 | 0.85 | PDE4B (0.57) | USP30PDE4BKDM4EMAPTTHRB | |
| SCHEMBL1015417 | 0.85 | PDE4B (0.57) | USP30PDE4BKDM4EMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081890-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008055847-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |